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PhD scholarship in Polymer Bound Fluorescent Hydrogen Peroxide Sensors interdisciplinary project Better Hydrogen Peroxide Sensors for Studying Bacterial Infections and Immune Responses

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Danmarks Tekniske Universitet

Lyngby-Taarbæk, 1 stilling

One PhD stipend is available at DTU Nanotech in Synthesis of Polymer Bound Fluorescent Hydrogen Peroxide Sensors for Biomedical Application.

Supported by the Danish Research Council for Independent Research (DFF-FTP), the position is part of a joint project - Better Hydrogen Peroxide Sensors for Studying Bacterial Infections and Immune Responses - between the Marine Biological Section, Department of Biology, University of Copenhagen; the Copenhagen University Hospital (Rigshospitalet); and DTU Nanotechnology. The aim of the project is to develop and apply new experimental tools for optical sensing of hydrogen peroxide (H2O2), which is an important intermediate or byproduct in cell metabolism, especially under stressful conditions, and may act as an anti-microbial agent and signal molecule during infection. Currently, optical H2O2 detection in biomedical and biological sciences is limited to use of optical indicators that react irreversibly with peroxide and thus mainly show where H2O2 has been present prior to detection. Quantification of H2O2 concentration and dynamics is in most cases not possible by such means. The project aims to alleviate these current limitations and combines strong expertise in fiber-optic microsensors, optical sensor and polymer chemistry for the development of better optical H2O2 sensors. The new sensors will be applied in biomedical studies of chronic infections, where H2O2 is a central component in the battle between pathogenic bacteria and the host immune system. The project is a joint venture of the Department of Biology (University of Copenhagen), DTU Nanotech and the Department of Clinical Microbiology (Rigshospitalet). Extensive exchange between the three institutions is an essential part of the project.

Responsibilities and tasks
The PhD at DTU Nanotech will focus on the synthesis of new polymerizable indicators, their integration into a suitable matrix and on improving the stability of the sensor chemistry against biological and photochemical degradation.

We are seeking applications from researchers that hold a master's degree and are trained in polymer or small molecule synthesis, chemical engineering, analytical chemistry, or other technical disciplines relevant for the development and fabrication of optical chemical sensors. Applicants should have an interest in cross-disciplinary research and should be able to document a strong academic track record. Previous experience with optical chemical sensing and/or development and characterization of optical sensor systems will be regarded as strong assets.

Qualifications
Candidates should have a master's degree in engineering or a similar degree with an academic level equivalent to the master's degree in engineering.

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

Assessment
The assessment of the applicants will be made by Professor Kristoffer Almdal and the principal invstigators in the project from the University of Copenhagen.

We offer
We offer an interesting and challenging job in an international environment focusing on education, research, public-sector consultancy and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.

Workplace
Your main workplace will be at DTU Nanotech, but with frequent interactions and collaboration with project partners at the Copenhagen University Hospital (Rigshospitalet) and the the Marine Biological Section in Helsingør.

Further information
Further information may be obtained from Professor Kristoffer Almdal, tel: +45 4525 8114 – kral@nanotech.dtu.dk.

You can read more about DTU Nanotech on <a href='javascript:openLinkWindow("http://www.nanotech.dtu.dk")' "="" data-cke-saved-href='javascript:openLinkWindow("http://www.nanotech.dtu.dk")'>www.nanotech.dtu.dk.

Application
Please submit your online application no later than 15 November 2015. Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include:
•A letter motivating the application (cover letter)
•Curriculum vitae
•Grade transcripts and BSc/MSc diploma (an official translation into English)
•Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)

Candidates may apply prior to obtaining their master's degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU Nanotech - the Department of Micro- and Nanotechnology - is situated in the northern part of Copenhagen. DTU Nanotech is a centre of excellence in micro- and nanotechnology utilising sciences across the traditional boundaries of technology, thereby enabling innovative solutions for the benefit of society. DTU Nanotech has approx. 220 staff members. With 40 % international employees, the department constitutes an international environment.

DTU is a technical university providing internationally leading research, education, innovation and public service. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,300 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.